Actually this line is more likely to be in reference of the fact that Adam Sandler is known for putting his closest friends in his movies. So Wayne's saying he's always looking out for his clique like Adam Sandler does.
this lyric from Lil Wayne has a girl wondering how the gun will fire if it is made out of plastic in the following lyric of the song says "you see when ya boy run off" so Lil Wayne has told her the gun is made from plastic as to not worry her
"I got the floor" is a way of saying he has everyone's attention (the way a public speaker has "the floor" when addressing an audience). But he wants to do better than that; Lil' Wayne wants to be on top (on the "roof") of everything.
This could also be a reference to the fact that Lil' Wayne represents the Bloods gang, which are affiliated with the color red; their rival gang, the Crips, are affiliated with the color blue. Hence, the "blue" rivals he/his gang kills would be "ghosts."