in the card game spades, the more spades you have the have better your chance of winning. without spades you can't win. if the cards are dealt and you have no spades you can throw hand in (give up) - so, this lyric is saying you might as well give up.
The Game is saying he has (or is trying to get) as much money as Pablo Escobar, a drug lord from Colombia who was ruthless as he operated his drug empire (including cocaine which is often turned into crack cocaine) to gain money and power
Nicky Barnes was a high profile Harlem crime figure who was known as one of the biggest Heroin Kingpins in 1970's New York City. He was also known as Mr. Untouchable due to many failed prosecution attempts.
Kanye West is saying that just breaking his jaw in such a serious car accident is nothing and he is unbreakable (unlike Samuel L. Jackson in the movie Unbreakable who plays a character Mr. Glass whose bones break very easily).
this command of extreme disrespect stems from a joke where you ask someone if they would like some "fromunda cheese" - they of course will not know what it is, and you reply "cheese from unda my nuts!" (supposedly funny)